cAMP-dependent protein kinase inhibitor alpha (PKIA)

Function

• extremely potent competitive inhibitor of cAMP-dependent protein kinase (PKA) activity
• interacts with the PKA catalytic subunit after the cAMP-induced dissociation of its regulatory chains

Structure

• belongs to the PKI family
• the inhibitory site contains regions very similar to the hinge regions & 'pseudosubstrate site' of the PKA regulatory chains but, unlike these chains, PKI does not contain cAMP-binding sites
• the Arg within the inhibitory site are essential for inhibition & recognition of the enzyme active site

More general terms

• cAMP-dependent protein kinase inhibitor

Additional terms

• cAMP-dependent protein kinase catalytic subunit or protein kinase A [PKA] catalytic subunit

Database

• UniProt: http://www.uniprot.org/uniprot/P61925.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5569
• OMIM: https://mirror.omim.org/entry/606059