SLAM family member 7; CD2 subset 1; CD2-like receptor-activating cytotoxic cells; CRACC; membrane protein FOAP-12; Novel Ly9; protein 19A; signaling lymphocytic activation molecule F7; CD319 (SLAMF7, CS1, UNQ576/PRO1138)

Function

• isoform 1 mediates NK cell activation through a SH2D1A- independent extracellular signal-regulated ERK-mediated pathway
• may play a role in lymphocyte adhesion
• isoform 3 does not mediate any NK cell activation
• isoform 1 binds to SH2D1A when its cytoplasmic tail is phosphorylated in the presence of FYN (in vitro)

Structure

• contains 1 Ig-like C2-type domain

Compartment

• membrane; single-pass type 1 membrane protein

Alternative splicing

named isoforms=3

Expression

• expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung & trachea
• expressed in NK cells, activated B-cells, NK-cell line
• not expressed in promyelocytes, B-cell lines, or T-cell lines
• isoform 3 is expressed at much lower level than isoform 1

Pharmacology

• immunostimulatory monoclonal antibody elotuzumab (Empliciti) directed against SLAMF7 is FDA-approved to treat relapsed or refractory multiple myeloma

More general terms

• CD antigen
• SLAM family member protein
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=57823
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:57823
• OMIM: https://mirror.omim.org/entry/606625
• UniProt: http://www.uniprot.org/uniprot/Q9NQ25.html