CD244, natural killer cell receptor 2B4 (NKR2B4), NK cell type I receptor protein 2B4 (h2B4) or NK cell activation-inducing ligand (NAIL)

Function

• may modulate other receptor-ligand interactions to enhance leukocyte activation
• interacts with CD48
• after phosphorylation, recruits
  • PTPN11/SHP-2
  • SH2D1A/SAP
• binding of SH2D1A/SAP to CD244 prevents its association with PTPN11/SHP-2

Structure

contains 2 Ig-like (immunoglobulin-like) domains

Compartment

membrane

Alternative splicing

named isoforms=4

Expression

• expressed in NK cells, monocytes, basophils, spleen, lung liver, testis, small intestine

More general terms

• CD antigen
• cell surface receptor
• phosphoprotein
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5174
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51744
• OMIM: https://mirror.omim.org/entry/605554
• UniProt: http://www.uniprot.org/uniprot/Q9BZW8.html