hyaluronan mediated motility receptor; intracellular hyaluronic acid-binding protein; receptor for hyaluronan-mediated motility; CD168 (HMMR, IHABP, RHAMM)

Function

• role in cell motility
• hyaluronan binding results in phosphorylation of a number of proteins, including the focal adhesion kinase
• may also be involved in regulating extracellular-regulated kinase (ERK) activity
• subunit of the HARC complex

Compartment

cell surface, cytoplasm (putative)

Alternative splicing

named isoforms=2

Expression

• expressed in breast cancer cell lines & in normal breast tissue

Pathology

• may be involved in cellular transformation & metastasis

More general terms

• CD antigen
• cell surface receptor
• phosphoprotein
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3161
• OMIM: https://mirror.omim.org/entry/600936
• UniProt: http://www.uniprot.org/uniprot/O75330.html