CD157; ADP-ribosyl cyclase 2; cyclic ADP-ribose hydrolase 2; bone marrow stromal antigen 1 (BST1)

Function

• synthesizes cyclic ADP-ribose, a second messenger that elicits Ca+2 release from intracellular stores
• may be involved in pre-B-cell growth

NAD+ + H2O <--> ADP-ribose + nicotinamide

Structure

• homodimer
• belongs to the ADP-ribosyl cyclase family

Compartment

cell membrane; lipid-anchor, GPI-anchor

Expression

widely expressed

Pathology

• patients with rheumatoid arthritis show enhanced expression of CD157 transcripts in bone marrow stromal cell lines; thus CD157 overexpression may play a role in B-cell abnormalities in rheumatoid arthritis

More general terms

• CD antigen
• hydrolase
• glypiated protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=683
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:683
• OMIM: https://mirror.omim.org/entry/600387
• UniProt: http://www.uniprot.org/uniprot/Q10588.html