CD83 antigen; cell surface protein HB15; B-cell activation protein (CD83)

Function

• may play a role in antigen presentation or cellular interactions that follow lymphocyte activation

Structure

• monomer
• contains 1 Ig-like V-type domain (immunoglobulin-like)

Compartment

membrane

Expression

• expressed by activated lymphocytes, Langerhans cells & interdigitating reticulum cells
• marker for dendritic cells
  • non-follicular dendritic cells
  • circulating dendritic cells
  • interdigitating dendritic cells within lymphoid tissues
  • Langerhan's cells
  • in vitro generated dendritic cells
  • thymic dendritic cells
  • weak reactivity with some lymphoblastoid cell lines & with some germinal center B cells in vivo

Pathology

• expressed in inflammatory infiltrates of Churg-Strauss syndrome myocarditis

More general terms

• CD antigen
• glycoprotein
• immunoglobulin superfamily protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q01151.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9308
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9308
• OMIM: https://mirror.omim.org/entry/604534