G antigen family B member 1; AL5; G antigen 9; GAGE-9; prostate-associated gene 1 protein; PAGE-1 (PAGE1 GAGE9 GAGEB1)

Function

• antigen
  • recognized on tumors by autologous cytolytic T-cells (see Genetics:)

Structure

belongs to the GAGE family

Expression

• normal testis
• placenta
• prostate cancer
• testicular cancer

Genetics

• gene belongs to a family of genes organized in clustered repeats
  • the genes have a high degree of predicted sequence identity, but differ by scattered single nucleotide substitution
  • their sequences contain either the antigenic peptide YYWPRPRRY or YRPRPRRY which is recognized by cytotoxic T-cells

More general terms

• GAGE protein (G antigen family)
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8712
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8712
• OMIM: https://mirror.omim.org/entry/300288
• UniProt: http://www.uniprot.org/uniprot/O75459.html