ethanolaminephosphotransferase 1; hEPT1; selenoprotein I; selI (EPT1, KIAA1724, SELI)

Function

• catalyzes phosphatidylethanolamine biosynthesis from CDP-ethanolamine
• role in formation & maintenance of vesicular membranes
• role in formation of phosphatidylethanolamine via Kennedy pathway
• phospholipid metabolism; phosphatidylethanolamine
• biosynthesis; phosphatidylethanolamine from ethanolamine: step 3/3

Cofactor: Mg+2 or Mn+2

Kinetic parameters:

• KM=1.8 uM for CDP-ethanolamine
• Vmax=76.3 pmol/min/mg enzyme with CDP-ethanolamine as substrate

Structure

• belongs to the CDP-alcohol phosphatidyltransferase class-I family

Compartment

membrane

Expression

• widely expressed
• expressed in brain, placenta, liver & pancreas > heart, skeletal muscle, lung & kidney
• in brain, expressed in cerebellum > occipital pole & frontal lobe

More general terms

• ethanolamine phosphotransferase
• selenoprotein
• transmembrane 10 protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=85465
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:85465
• OMIM: https://mirror.omim.org/entry/607915
• UniProt: http://www.uniprot.org/uniprot/Q9C0D9.html