peroxisomal N1-acetyl-spermine/spermidine oxidase (polyamine oxidase, PAOX, PAO, UNQ1923/PRO4398)

Function

• flavoenzyme involve in polyamine catabolism
• catalyzes oxidation of N(1)-acetylspermine to spermidine & is thus involved in the polyamine back-conversion
• can also oxidize N(1)-acetylspermidine to putrescine
• substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine
• does not oxidize spermidine
• role in regulation of polyamine intracellular concentration
• cellular sensitivity to antitumor polyamine analogs

N(1)-acetylspermine + O2 + H2O <--> N(1)-acetylspermidine + 3-aminopropanal + H2O2

Cofactor: FAD

Structure

belongs to the flavin monoamine oxidase family

Compartment

peroxisome, cytoplasm

Alternative splicing

named isoforms=11

Expression

• widely expressed
• not detected in spleen
• induced by polyamine analogs

Pathology

• expressed at lower level in neoplastic tissues

More general terms

• enzyme

Database

• UniProt: http://www.uniprot.org/uniprot/Q6QHF9.html