single-strand selective monofunctional uracil DNA glycosylase

Function

• recognizes base lesions in the genome
• initiates base excision DNA repair
• monofunctional DNA glycosylase specific for uracil (U) residues in DNA
• preference for single-stranded DNA substrates
• activity is greater against mismatches (U/G) than against matches (U/A)
• excises uracil, 5-formyluracil & uracil derivatives with an oxidized group at C5 [5-hydroxyuracil & 5-hydroxy- methyluracil] in ssDNA & dsDNA

Compartment

nucleus

Alternative splicing

named isoforms=2

More general terms

• enzyme

Database

• OMIM: https://mirror.omim.org/entry/607753
• UniProt: http://www.uniprot.org/uniprot/Q53HV7.html