oxytocin-neurophysin 1; OT-NPI; contains: oxytocin; neurophysin 1 (OXT, OT)

Function

• precursor for
  • oxytocin
    • oxytocin causes contraction of the smooth muscle of the uterus & of the mammary gland
  • neurophysin 1
    • neurophysin 1 specifically binds oxytocin

Structure

• belongs to the vasopressin/oxytocin family

Compartment

secreted

Pharmacology

• oxytocin is available under the names pitocin (Parke-Davis) & syntocinon (Sandoz)
• used to artificially speed or induce labor

More general terms

• protein precursor
• peptide precursor
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5020
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5020
• OMIM: https://mirror.omim.org/entry/167050
• UniProt: http://www.uniprot.org/uniprot/P01178.html