prepro-vasopressin; vasopressin-neurophysin 2 copeptin (AVP)

Function

• precursor for
  • arginine vasopressin
  • neurophysin 2
    • neurophysin 2 specifically binds vasopressin
  • copeptin

Structure

belongs to the vasopressin/oxytocin family

Compartment

secreted

Pathology

• defects in AVP are the cause of
  • autosomal dominant neurohypophyseal diabetes insipidus
  • autosomal recessive neurohypophyseal diabetes insipidus
• disruption of preproAVP-NPII processing believed to play a role

More general terms

• protein precursor
• peptide precursor
• glycoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=551
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:551
• OMIM: https://mirror.omim.org/entry/125700
• OMIM: https://mirror.omim.org/entry/192340
• UniProt: http://www.uniprot.org/uniprot/P01185.html