adherens junction-associated protein 1; membrane protein shrew-1 (AJAP1, MOT8, SHREW1)

Function

• role in cell adhesion & cell migration
• forms a complex with CDH1 & CTNNB1
• interacts directly with CTNNB1
• interacts with AP1M2 & BSG/CD147
• Thr-237 & Ser-239 may be phosphorylated; however as this position is probably extracellular, the vivo relevance is uncertain

Compartment

• basolateral cell membrane
• apical cell membrane
• cell junction, adherens junction
• mainly basolateral
• localization is mediated by AP1M2

Expression

expressed in uterus & pancreas (at protein level)

More general terms

• adhesion protein
• membrane protein
• phosphoprotein

Additional terms

• adherens junction; zonula adherens; belt desmosome

Database

• UniProt: http://www.uniprot.org/uniprot/Q9UKB5.html