protein spire homolog 1 (spir-1, SPIRE1, KIAA1135, SPIR1)

Function

• acts as a actin nucleation factor
• remains associated with the slow-growing pointed end of the new filament
• involved in vesicle transport processes providing a novel link between actin organization & intracellular transport

Structure

• binds to actin monomers via the WH2 domain
• Spir-box targets binding to intracellular membrane structures
• belongs to the spire family
• contains 2 WH2 domains

Compartment

• cytoplasm
• punctate spots in perinuclear region & cytoplasm, co-localised with Rab11

Alternative splicing

named isoforms=2

More general terms

• phosphoprotein
• cytoskeletal protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q08AE8.html