inter-alpha-trypsin inhibitor heavy chain H5 (ITI heavy chain H5, inter-alpha-inhibitor heavy chain 5) (ITIH5 KIAA1953 UNQ311/PRO354)

Function

may act as a tumor suppressor

Structure

• belongs to the ITIH family
• contains 1 VWFA domain

Compartment

secreted (putative)

Alternative splicing

named isoforms=3

Expression

• abundantly expressed in placenta
• less abundant expression in mammary gland & ovary
• expression is barely detectable levels in all other tissues tested

Pathology

down-regulated in breast tumors

More general terms

• secreted protein
• glycoprotein
• anti-oncoprotein (tumor suppressor protein)

Database

• UniProt: http://www.uniprot.org/uniprot/Q86UX2.html