Intron-binding protein aquarius (intron-binding protein of 160 kD, IBP160, AQR, KIAA0560)

Function

• intron-binding spliceosomal protein required to link pre-mRNA splicing & snoRNP (small nucleolar ribonucleoprotein) biogenesis.
• role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly.
• may assist folding of the snoRNA sequence
• binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA & the branchpoint of introns (40 nucleotides upstream of the branchpoint) during late stages of splicing
• identified in the spliceosome C complex

Structure

belongs to the CWF11 family

Compartment

• nucleus
• localizes to speckle-like regions of the nucleoplasm

More general terms

• RNA-binding protein

Component of

• spliceosome C complex

Database

• UniProt: http://www.uniprot.org/uniprot/O60306.html