pumilio homolog 1 (pumilio-1, HsPUM, PUM1, KIAA0099, PUMH1)

Function

• sequence-specific RNA-binding protein
• regulates translation & mRNA stability by binding the 3' untranslated regions (UTRs) of mRNA targets
• role in proliferation & self-renewal of stem cells (putative)
• binds in a sequence-specific manner to the 3'UTR of some mRNAs
• pumilio repeats mediate the association with RNA by packing together to form a right-handed superhelix that approximates a half donut- number as well as the specific sequence of repeats determine specificity for target mRNAs

Structure

• contains 1 PUM-HD domain
• contains 8 pumilio repeats

Compartment

cytoplasm

Alternative splicing

named isoforms=2

Expression

• expressed in brain, heart, kidney, muscle, intestine, stomach
• not expressed in cerebellum, corpus callosum, caudate nucleus, hippocampus, medulla oblongata, putamen
• expressed in all fetal tissues tested
• down-regulated in keratinocytes upon ultraviolet B radiation

More general terms

• RNA-binding protein

Database

• OMIM: https://mirror.omim.org/entry/607204
• UniProt: http://www.uniprot.org/uniprot/Q14671.html