programmed cell death protein 11; protein RRP5 homolog; NF-kappa-B-binding protein; NFBP (PDCD11, KIAA0185)

Function

• essential for the generation of mature 18S rRNA,
• specifically necessary for cleavages at sites A0, 1 & 2 of the 47S rRNA precursor
• directly interacts with U3 snoRNA
• role in the biogenesis of rRNA (putative)
• interacts with NF-kappa-B p50/NFKB1 & NF-kappa-B p65/RELA

Structure

• contains 4 HAT repeats
• contains 12 S1 motif domains

Compartment

nucleus, nucleolus

More general terms

• RNA-binding protein
• nuclear protein
• phosphoprotein

Additional terms

• apoptosis
• programmed cell death protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=22984
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:22984
• OMIM: https://mirror.omim.org/entry/612333
• UniProt: http://www.uniprot.org/uniprot/Q14690.html