glycerol-3-phosphate acyltransferase-like protein 1 (xGPAT1, GPAT2)

Function

• role in acylation of glycerol-3-phosphate
• phospholipid metabolism; CDP-diacylglycerol biosynthesis
• CDP-diacylglycerol from sn-glycerol 3-phosphate: step 1/3

acyl-CoA + sn-glycerol 3-phosphate
             <-->
CoA + 1-acyl-sn-glycerol 3-phosphate

Structure

• HXXXXD motif is essential for acyltransferase activity & may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate (putative)
• belongs to the GPAT/DAPAT family

Compartment

membrane

Alternative splicing

named isoforms=5

More general terms

• acyltransferase
• membrane protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q6NUI2.html