EGFR-coamplified & overexpressed protein; ECop; glioblastoma-amplified secreted protein; NF-kappa-B-activating protein 055N (ECOP, GASP, VOPP1)

Function

• increases the transcriptional activity of NFKB1 by facilitating its nuclear translocation, DNA-binding & associated apoptotic response, when overexpressed

Structure

belongs to the ECOP family

Compartment

• nucleus, membrane
• when overexpressed, localizes in the nucleus & perinuclear regions

More general terms

• nuclear protein
• membrane protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7290
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8155
• UniProt: http://www.uniprot.org/uniprot/Q96AW1.html