protein GREB1 (gene regulated in breast cancer 1 protein, GREB1, KIAA0575)

Function

• primary target for estrogen receptor regulation

Structure

belongs to the GREB1 family

Compartment

membrane (putative)

Alternative splicing

named isoforms=4

Expression

• expressed in proliferating prostatic tissue & prostate cancer
• estrogen-responsive, regulated by estrogen receptors
• regulatory region of the gene contains 3 estrogen-responsive elements
• regulated by androgens

Pathology

• acts as a regulator of hormone-dependent cancer growth in breast & prostate cancers

More general terms

• membrane protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9687
• UniProt: http://www.uniprot.org/uniprot/Q4ZG55.html