Ca+2-binding mitochondrial carrier protein SCaMC-3 (small Ca+2-binding mitochondrial carrier protein 3, mitochondrial ATP-Mg/Pi carrier protein 2, mitochondrial Ca+2-dependent solute carrier protein 2, solute carrier family 25 member 23, SLC25A23, APC2, MCSC2, SCAMC3)
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Function
- Ca+2-dependent mitochondrial solute carrier
- mitochondrial solute carriers shuttle metabolites, nucleotides, & cofactors through the mitochondrial inner membrane
- may act as ATP-Mg/Pi exchanger that mediates the transport of Mg-ATP in exchange for phosphate, catalyzing the net uptake or efflux of adenine nucleotides into or from the mitochondria
- may interact with hepatitis B virus (HBV) protein S
- KM=1.3 mM for AMP
- KM=0.54 mM for ADP
- KM=0.31 mM for ATP
- KM=0.22 mM for ATP-Mg
- KM=1.4 mM for Pi
- Vmax=68 umol/min/g enzyme with AMP as substrate
- Vmax=73 umol/min/g enzyme with ADP as substrate
- Vmax=65 umol/min/g enzyme with ATP as substrate
- Vmax=79 umol/min/g enzyme with ATP-Mg as substrate
- Vmax=70 umol/min/g enzyme with Pi as substrate
Structure
- belongs to the mitochondrial carrier family
- contains 3 EF-hand domains
- contains 3 solcar repeats
Compartment
mitochondrial inner membrane
Alternative splicing
named isoforms=4
Expression
- present in various cell lines (at protein level)
- expressed at low levels in most tissues examined
- highest expression in brain, skeletal muscle & pancreas
More general terms
- membrane protein
- Ca+2 binding protein
- mitochondrial protein
- solute carrier family 25 (SLC25, SLC25A)