S-adenosylmethionine mitochondrial carrier protein (mitochondrial S-adenosylmethionine transporter, solute carrier family 25 member 26, SLC25A26, SAMC)

Function

• mitochondrial solute carriers shuttle metabolites, nucleotides, & cofactors through the mitochondrial inner membrane
• specifically mediates the transport of S-adenosylmethionine (SAM) into the mitochondria
• strongly inhibited by tannic acid & bromocresol Purple

Structure

• belongs to the mitochondrial carrier family
• contains 3 solcar repeats

Compartment

mitochondrial inner membrane

Alternative splicing

named isoforms=3

Expression

• widely expressed
• highly expressed in testis,
• moderate expression in brain, heart, kidney, lung, skeletal muscle, pancreas, small intestine & liver
• low expression in spleen

More general terms

• mitochondrial protein
• membrane protein
• solute carrier family 25 (SLC25, SLC25A)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1152
• UniProt: http://www.uniprot.org/uniprot/Q70HW3.html