3-oxo-5-alpha-steroid 4-dehydrogenase 3; steroid 5-alpha reductase 3; testosterone 5-alpha reductase 3; SR type 3; steroid 5-alpha-reductase 2-like (SRD5A3, SRD5A2L)

Function

• converts testosterone into 5-alpha-dihydrotestosterone

3-oxo-5-alpha-steroid + acceptor
                   <-->
3-oxo-delta(4)-steroid + reduced acceptor

Structure

belongs to the steroid 5-alpha reductase family

Compartment

microsome membrane

Expression

almost no or little expression in normal adult organs

Pathology

• overexpressed in hormone-refractory prostate cancers

More general terms

• 3-oxo-5-alpha-steroid 4 dehydrogenase
• membrane protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7964
• UniProt: http://www.uniprot.org/uniprot/Q9H8P0.html