UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter (solute carrier family 35 member D2, UDP-galactose transporter-related protein 8, UGtrel8, SQV7-like protein, SQV7L, homolog of Fringe connection protein 1, HFRC1, SLC35D2, HFRC, UGTREL8)
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Function
- antiporter transporting nucleotide sugars such as UDP-N-acetylglucosamine (UDP-GlcNAc), UDP-glucose (UDP-Glc) & GDP-mannose (GDP-Man) pooled in the cytosol into the lumen of the Golgi in exchange for the corresponding nucleoside monophosphates (UMP for UDP-sugars & GMP for GDP-sugars)
- may take part in heparan sulfate synthesis by supplying UDP-Glc-NAc, the donor substrate, & thus be involved in growth factor signaling
- KM=8 uM for UDP-N-acetylglucosamine
- KM=2.1 uM for UDP-glucose
- KM=0.14 uM for GDP-mannose
Structure
- belongs to the TPT transporter family, SLC35D subfamily
Compartment
Golgi membrane
Alternative splicing
named isoforms=2
Expression
- highly expressed in heart, kidney, small intestine, placenta, lung & peripheral blood leukocyte
- weakly expressed in skeletal muscle & spleen
- not expressed in brain, colon & thymus