N-acetylated-alpha-linked acidic dipeptidase-like protein 2 (NAALADase L2, NAALADL2)

Function

may be catalytically inactive

Structure

• belongs to the peptidase M28 family, M28B subfamily
• although related to the peptidase M28 family, it is probably inactive as an hydrolase due to lack of the conserved Zn+2-binding & active sites

Compartment

membrane

Alternative splicing

named isoforms=2

Expression

• expressed at high level in kidney & placenta
• in embryo, it is mainly confined to duodenal & stomach endoderm, mesonephros, metanephros & pancreas

Genetics

• gene maps to 3q26.31, a region associated with Cornelia de Lange syndrome
• specific mutations in a panel of DNA samples from patients with Cornelia de Lange syndrome not identified

More general terms

• glycoprotein
• membrane protein

Database

• OMIM: https://mirror.omim.org/entry/608806
• UniProt: http://www.uniprot.org/uniprot/Q58DX5.html