endoplasmic reticulum aminopeptidase 2 (leukocyte-derived arginine aminopeptidase, L-RAP, ERAP2, LRAP)

Function

• aminopeptidase
• role in peptide trimming
• preferentially hydrolyzes the basic residues Arg & Lys heterodimer; with ERAP1

Cofactor: binds 1 Zn+2 per subunit (putative)

Structure

• N-glycosylated
• belongs to the peptidase M1 family

Compartment

• endoplasmic reticulum membrane

Alternative splicing

named isoforms=4

Expression

• ubiquitously expressed
• highly expressed in spleen & leukocytes
• induced by IFN-gamma

Pathology

• defects in the expression of this gene may cause improper antigen processing, possibly leading to favor tumor escape from the immune surveillance

More general terms

• aminopeptidase
• glycoprotein
• membrane protein

Additional terms

• endoplasmic reticulum aminopeptidase (ERAP)

Database

• UniProt: http://www.uniprot.org/uniprot/Q6P179.html