autophagy-related protein 9B (APG9-like 2, nitric oxide synthase 3-overlapping antisense gene protein, protein sONE, ATG9B, APG9L2, NOS3AS)

Function

• plays a role in autophagy (putative)

Structure

belongs to the ATG9 family

Compartment

cytoplasmic vesicle, autophagosome membrane

Alternative splicing

named isoforms=3

Expression

• highly expressed in placenta (trophoblast cells) & pituitary gland
• not expressed in vascular endothelium
• induced by hypoxia, leading to inhibit NOS3 expression

Genetics

• ATG9B gene is located on the opposite DNA strand of the NOS3 gene at chromosome 7q36
• the genes are oriented in a tail-to-tail configuration & the mRNAs encoding ATG9B & NOS3 are complementary for 662 nucleotides
• ATG9B transcription may a role in NOS3 transcription regulation

More general terms

• membrane protein
• autophagy protein (autophagy-related protein)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2859
• UniProt: http://www.uniprot.org/uniprot/Q674R7.html