sphingolipid delta(4)-desaturase/C4-hydroxylase DES2 (degenerative spermatocyte homolog 2, DEGS2)

Function

• bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase & a sphingolipid C4-hydroxylase
• lipid biosynthesis, sphingolipid biosynthesis

Structure

• belongs to the fatty acid desaturase family, DEGS subfamily

Compartment

endoplasmic reticulum membrane

Expression

• highly expressed in skin, intestine & kidney
• up-regulated during keratinocyte differentiation
• not expressed at day 0 or day 3 after differentiation, detected on day 6 & increases by day 9

More general terms

• oxidoreductase
• myristoylated protein
• membrane protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q6QHC5.html