UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2 (beta-1,3-N-acetylgalactosaminyltransferase 2, beta-3-GalNAc-T2, B3GALNT2)

Function

• beta-1,3-N-acetylgalactosaminyltransferase active in synthesizing a unique carbohydrate structure, GalNAc-beta-1-3GlcNAc, on N- & O-glycans
• has no galactose nor galactosaminyltransferase activity toward any acceptor substrate

Kinetic parameters:

• KM=5.4 uM for UDP-GalNAc
• KM=11 mM for GlcNAc-beta-Bn

Structure

• belongs to the glycosyltransferase 31 family
• N-glycosylated (probable)

Compartment

Golgi membrane

Alternative splicing

named isoforms=2

Expression

• expressed in all tissues examined
• highest levels in testis, adipose tissue, skeletal muscle & ovary

More general terms

• beta-1,3-N-acetylgalactosaminyltransferase
• membrane protein
• glycoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8NCR0.html