transmembrane protein 55A (type 2 phosphatidylinositol 4,5-bisphosphate 4-phosphatase, Ptdins-4,5-P2 4-Ptase 2, TMEM55A)

Function

• catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate
• does not hydrolyze
  • phosphatidylinositol 3,4,5-trisphosphate
  • phosphatidylinositol 3,4-bisphosphate
  • inositol 3,5-bisphosphate
  • inositol 3,4-bisphosphate
  • phosphatidylinositol 5-monophosphate
  • phosphatidylinositol 4-monophosphate
  • phosphatidylinositol 3-monophosphate

1-phosphatidyl-myo-inositol 4,5-bisphosphate + H2O
                   <-->
1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate

Compartment

• late endosome membrane
• lysosome membrane

Expression

ubiquitous

More general terms

• phosphomonoesterase
• membrane protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8N4L2.html