glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (core 1 beta1,3-galactosyltransferase 1, core1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1, core 1 beta3-Gal-T, C1GalT1, beta 1,3-galactosyltransferase, core 1 O-glycan T-synthase, B3Gal-T8, C1GALT1)
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Function
- glycosyltransferase
- generates core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), a precursor for many extended O-glycans in glycoproteins
- role in many processes, including angiogenesis, thrombopoiesis & kidney homeostasis development
- glycosylation
- interacts with the C1GALT1C1 chaperone; required for galactosyltransferase activity
UDP-galactose + glycoprotein N-acetyl-D-galactosamine
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UDP + glycoprotein D-galactosyl-1,3-N-acetyl-D-galactosamine
Cofactor: Mg+2
Structure
- belongs to the glycosyltransferase 31 family, Beta3- Gal-T subfamily
- homodimer, disulfide-linked (putative)
Compartment
membrane
Alternative splicing
named isoforms=2
Expression
- widely expressed
- highly expressed in kidney, heart, placenta & liver
Pathology
- defects in C1GALT1 may be a cause of susceptibility to IgA nephropathy