beta-1,4 N-acetylgalactosaminyltransferase 2 (Sd(a) beta-1,4-GalNAc transferase, UDP-GalNAc:Neu5Aca2-3Galb-R b1,4-N-acetylgalactosaminyltransferase, B4GALNT2, GALGT2)

Function

• glycosylation
  • role in synthesis of the Sd(a) antigen
  • transfers a beta-1,4-linked GalNAc to the galactose residue of an alpha-2,3-sialylated chain

Structure

belongs to the glycosyltransferase 2 family

Compartment

Golgi membrane

Alternative splicing

named isoforms=2

Expression

• widely expressed
• expressed in colon > kidney, stomach, ileum & rectum

More general terms

• beta-1,4-N-acetylgalactosaminyltransferase (B4GALNT)
• glycoprotein
• membrane protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8NHY0.html