alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B; mannoside acetylglucosaminyltransferase 5B; alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase B; N-acetylglucosaminyl-transferase Vb; GNT-Vb; GlcNAc-T Vb; hGnTVb; N-acetylglucosaminyltransferase IX; GNT-IX (MGAT5B, KIAA2008)
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Function
- glycosyltransferase, role in glycosylation
- acts on alpha-linked mannose of N-glycans & O-mannosyl glycans
- catalyzes transfer of N-acetylglucosamine (GlcNAc) to the beta 1-6 linkage of the mannose residue of GlcNAcbeta1,2-Manalpha on both the alpha1,3- & alpha1,6- linked mannose arms in the core structure of N-glycan
- also acts on GlcNAcbeta1,2-Manalpha1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan
- role in modulating integrin & laminin-dependent adhesion & migration of neuronal cells via its activity in the O-mannosyl glycan pathway
Cofactor: divalent metal cations (controversial)
Structure
belongs to the glycosyltransferase 18 family
Compartment
Golgimembrane
Alternative splicing
named isoforms=4
Expression
- predominantly expressed in brain
- expressed in all areas of the adult & fetal brain
- expressed at much lower level in testis, spleen, thymus