laeverin; CHL2 antigen (LVRN, AQPEP)

Function

• probable metalloprotease
• role in extravillous trophoblasts function
• binds 1 Zn+2 per subunit

Structure

belongs to the peptidase M1 family

Compartment

• membrane

Alternative splicing

named isoforms=4

Expression

• specifically expressed in placenta & NOT in other tissues
  • found at the cell surface region of extravillous trophoblasts
  • detected on extravillous trophoblasts in the outer layer of chorion laeve in the fetal membrane
  • not detected on either fetal amniotic epithelial cells or maternal decidual cells
  • also detected in the migrating extravillous trophoblasts in the maternal decidual tissues

More general terms

• metalloprotease
• membrane protein
• glycoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q6Q4G3.html