proprotein convertase PC4 (proprotein convertase subtilisin/kexin type 4, PCSK4, PC4, UNQ2757/PRO6496)

Function

• role in processing of hormone & other protein precursors at sites of pairs of basic amino acid residues
• role in transcriptional coactivation
• role ion stabilizing the multiprotein transcription complex (putative)

Structure

• belongs to the peptidase S8 family, Furin subfamily
• contains 1 FU repeat (furin-like repeat)

Compartment

membrane

Alternative splicing

named isoforms=2

Expression

• expressed in placenta
• localized predominantly in the cytotrophoblast layer of trophoblast cells during the 1st trimester of pregnancy & to the syncytiotrophoblast & stroma cells during the 3rd trimester

More general terms

• serine protease
• glycoprotein
• membrane protein

Database

• OMIM: https://mirror.omim.org/entry/600487
• UniProt: http://www.uniprot.org/uniprot/Q6UW60.html