poly [ADP-ribose] polymerase 16; ADP-ribosyltransferase diphtheria toxin-like 15; ARTD15; mono [ADP-ribose] polymerase PARP16; PARP-16 (PARP16, C15orf30)

Function

• mono ADP-ribosyltransferase targeting the karyopherin KPNB1
• interacts with KPNB1

Structure

• the N-terminal PARP alpha-helical domain is regulatory
  • it packs against the catalytic domain, & may relay effector-binding event to the NAD-binding site
• contains 1 PARP alpha-helical domain
• contains 1 PARP catalytic domain

Compartment

• nuclear membrane
• endoplasmic reticulum membrane
• single-pass membrane protein

Alternative splicing

named isoforms=3

More general terms

• NAD+ ADP-ribosyltransferase or poly ADP-ribose polymerase
• membrane protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=54956
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:54956
• UniProt: http://www.uniprot.org/uniprot/Q8N5Y8.html