DBH-like monooxygenase protein 1 (monooxygenase X, MOXD1, MOX, UNQ2493/PRO5780)
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Function
- may play role in biosynthesis of norepinephrine
Cofactor: binds 2 copper ions per subunit (putative)
Structure
- belongs to the copper type II ascorbate-dependent monooxygenase family
- contains 1 DOMON domain
- N-glycosylated (putative)
Compartment
endoplasmic reticulum membrane (putative)
Alternative splicing
named isoforms=2 Note=Major
Expression
- highly expressed in lung, kidney, brain & spinal cord
- expressed in fetal liver & fetal brain
- induced by replicative senescence (terminal differentiation) in fibroblasts[2]
Genetics
- gene located on chromosome 6q24, a region linked with exceptional episodic memory in elders[3]
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q6UVY6.html
- ↑ 2.0 2.1 Chambers KJ, Tonkin LA, Chang E et al Identification and cloning of a sequence homologue of dopamine beta-hydroxylase. Gene. 1998 Sep 18;218(1-2):111-20 PMID: https://www.ncbi.nlm.nih.gov/pubmed/9751809
- ↑ 3.0 3.1 Barral S et al. Common genetic variants on 6q24 associated with exceptional episodic memory performance in the elderly. JAMA Neurol 2014 Oct 13 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/25317765 <Internet> http://archneur.jamanetwork.com/article.aspx?articleid=1915580