hepatocyte cell adhesion molecule (protein hepaCAM, HEPACAM)
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Function
- role in regulating cell motility & cell-matrix interactions
- may inhibit cell growth through suppression of cell proliferation
- homodimer, dimer formation occurs predominantly through cis interactions on the cell surface
Structure
- cytoplasmic domain plays an important role in regulation of cell-matrix adhesion & cell motility
- contains 1 Ig-like C2-type domain (immunoglobulin-like)
- contains 1 Ig-like V-type domain (immunoglobulin-like)
- N-glycosylated
Compartment
- cytoplasm, membrane, cytoplasmic side
- in MCF7 breast carcinoma & hepatic Hep3B & HepG2 cell lines, localization of HEPACAM is cell density-dependent
- in well spread cells, localized to punctate structures in the perinuclear membrane, cytoplasm, & at cell surface of protusions
- in confluent cells, localized predominantly to the cytoplasmic membrane, particularly in areas of cell-cell contacts
- colocalizes with CDH1
Alternative splicing
named isoforms=2
Expression
- down-regulated in 20 out of 23 of hepatocellular carcinoma (HCC) samples & is undetectable in 5 HCC cell lines tested