small breast epithelial mucin; protein (BS106, SBEM, MUCL1)

Function

• O-glycosylated (probable)

Compartment

secreted (probable), membrane (Probable)

Expression

• expressed in mammary gland, salivary glands & prostate
• detected in lung

Pathology

• may play a role as marker for diagnosis of metastatic breast cancer
• mainly expressed in cancer cell lines of breast origin
• highly expressed in lymph node-positive compared with node-negative breast cancer
• detected in all lymph node containing metastatic breast cancer cells

Polymorphism

The number of repeats varies from 3 to 2 in one variant form which is equally present in breast cancer tumors

More general terms

• membrane protein
• secreted protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q96DR8.html