proline-rich membrane anchor 1 (PRiMA) (PRIMA1)

Function

• required to anchor acetylcholinesterase (ACHE) to the basal lamina of the neuromuscular junction & to the membrane of neuronal synapses in brain
• able to organize ACHE into tetramers (putative)
• interacts with ACHE, probably through disulfide bonds

Structure

• proline-rich attachment domain (PRAD) binds the AChE catalytic subunits (putative)
• contains 1 PRAD domain (Pro-rich attachment domain)

Compartment

membrane

Alternative splicing

named isoforms=2

More general terms

• membrane protein
• glycoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/Q86XR5.html