sperm acrosome membrane-associated protein 3 (sperm lysozyme-like protein 1, lysozyme-like protein 3, lysozyme-like acrosomal sperm-specific secretory protein ALLP-17, [Contains: Sperm acrosome membrane-associated protein 3, membrane form; Sperm acrosome membrane-associated protein 3, processed form], SPACA3, LYC3, LYZL3, SLLP1, UNQ424/PRO862)
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Function
- sperm surface membrane protein
- role in sperm-egg plasma membrane adhesion & fusion during fertilization
- putative receptor for egg oligosaccharide residue N-acetylglucosamine present in extracellular matrix over egg plasma membrane
- processed form has no detectable bacteriolytic activity in vitro
- processed form derives from membrane form by proteolytic processing
Structure
- belongs to the glycosyl hydrolase 22 family
- lacks the conserved Glu-122 & Asp-139 essential for lysozyme activity
Compartment
acrosome membrane
Alternative splicing
named isoforms=2 Expressuib:
- processed form is expressed in sperm (at protein level)
- expressed in testis, epididymis & placenta