mesoderm-specific transcript homolog protein (paternally-expressed gene 1 protein, MEST, PEG1)

Structure

• belongs to the AB hydrolase superfamily

Compartment

membrane

Alternative splicing

named isoforms=3

Expression

• biallelic expression is detected in blood lymphocytes
  • seems to imprinted in an isoform-specific manner rather than in a tissue-specific manner in lymphocytes
  • isoform 1 is expressed only from the paternal allele
  • isoform 2 is expressed from both the paternal allele & maternal allel
  • monoallelic expression of paternally derived allele observed in all fetal tissues examined, including brain, skeletal muscle, kidney, adrenal, tongue, heart, skin, & placenta
  • in 75-day fetus, expressed in the amnion, brain, heart, lung, stomach, gut, adrenal, kidney, muscle, & liver

Pathology

• highly expressed in hydatidiform moles
• barely expressed in dermoid cysts

More general terms

• membrane protein
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/601029
• UniProt: http://www.uniprot.org/uniprot/Q5EB52.html