vasorin (protein Slit-like 2, VASN, SLITL2, UNQ314/PRO357/PRO1282)

Function

• inhibitor of TGF-beta signaling (putative)
• interacts with TGFB1, TGFB2 & TGFB3

Structure

• N-glycosylated
• contains 1 EGF-like domain.
• contains 11 LRR repeats (leucine-rich repeats)

Compartment

membrane, secreted

Expression

• expressed in aorta > kidney, placenta > brain, heart, liver, lung, skeletal muscle
• within aorta, strongest expression in tunica media
• within kidney, expressed in interstitial cells

More general terms

• glycoprotein
• membrane protein
• secreted protein

Database

• OMIM: https://mirror.omim.org/entry/608843
• UniProt: http://www.uniprot.org/uniprot/Q6EMK4.html