3-keto-steroid reductase (estradiol 17-beta-dehydrogenase 7, 17-beta-HSD 7, 17-beta-hydroxysteroid dehydrogenase 7, HSD17B7)

Function

• reduction of the keto group on the C-3 of sterols
• estrogens biosynthesis
• sterols biosynthesis
• phosphorylated

4-alpha-methyl-5-alpha-cholest-7-en-3-beta-ol + NADP+
<-->
4-alpha-methyl-5-alpha-cholest-7-en-3-one + NADPH

Estradiol-17-beta + NADP+  <-->  estrone + NADPH

Compartment

membrane

Alternative splicing

named isoforms=3

Expression

• expressed in adrenal gland, liver, lung, thymus > breast, ovaries, pituitary gland, pregnant uterus, prostate, kidney, lymph node, small intestine, spinal cord, trachea > other tissues
• isoform 3 is expressed in eye ciliary epithelial cells & neuroendocrine cells

More general terms

• membrane protein
• dehydrogenase
• glycoprotein
• phosphoprotein

Database

• OMIM: https://mirror.omim.org/entry/606756
• UniProt: http://www.uniprot.org/uniprot/P56937.html