seizure 6-like protein (SEZ6L KIAA0927 UNQ2542/PRO6094)

Function

• tumor suppressor ?

Structure

• contains 3 CUB domains
• contains 5 Sushi domains (CCP/SCR domains)

Compartment

membrane

Alternative splicing

named isoforms=5

Expression

• widely expressed, including adult & fetal brain & lungs

Pathology

• not expressed in all lung cancer cell lines
• SEZ6L gene is located in a 22q region, which is frequently deleted in small cell lung carcinomas (SCLCs) & advanced non-small cell lung carcinomas

More general terms

• membrane protein
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/607021
• UniProt: http://www.uniprot.org/uniprot/Q9BYH1.html