membrane frizzled-related protein (MFRP)

Function

• role in eye development (putative)

Structure

• contains 2 CUB domains.
• contains 1 FZ domain (frizzled domain)
• contains 2 LDL-receptor class A domains

Compartment

membrane

Expression

• specifically expressed in brain, expressed in fetal brain
• expressed in medulla oblongata > hippocampus, corpus callosum
• expressed in keratinocytes

Pathology

• defects in MFRP are the cause of nanophthalmos 2

More general terms

• membrane protein
• glycoprotein

Database

• OMIM: https://mirror.omim.org/entry/606227
• UniProt: http://www.uniprot.org/uniprot/Q9BY79.html