kin of IRRE-like protein 2; kin of irregular chiasm-like protein 2; nephrin-like protein 3 (KIRREL2, NEPH3, UNQ5827/PRO19646)

Function

• interacts with C-terminus of NPHS2/podocin
• interacts with NPHS1 via Ig domains (putative)

Structure

• belongs to the immunoglobulin superfamily
• contains 5 Ig-like C2-type domains

Compartment

• membrane: single-pass type 1 membrane protein

Alternative splicing

named isoforms=4

Expression

• expressed in beta-cells of pancreatic islets

More general terms

• membrane protein
• glycoprotein

Additional terms

• nephrin; renal glomerulus-specific cell adhesion receptor (NPHS1 NPHN)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=84063
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:84063
• OMIM: https://mirror.omim.org/entry/607762
• UniProt: http://www.uniprot.org/uniprot/Q6UWL6.html