podoplanin; Aggrus; glycoprotein 36; Gp36; PA2.26 antigen; T1-alpha; T1A (PDPN, GP36, PSEC0003, PSEC0025, D2-40)

Function

• mucin like protein
• may play role in tumor progression
• cell migration &/or actin cytoskeleton organization
• lung cell proliferation & alveolus formation at birth
• induces platelet aggregation
• when expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility & decreased cell adhesion
• does not have any effect on folic acid or amino acid transport
• does not function as a water channel or as a regulator of aquaporin-type water channels

Structure

• belongs to the podoplanin family
• O-glycosylation (sialic acid) necessary for platelet aggregation
• the N-terminus is blocked (putative)

Compartment

• localized to actin-rich microvilli & plasma membrane projections (filopodia, lamellipodia, ruffles)
• apical plasma membrane of endothelium

Alternative splicing

named isoforms=2

Expression

• expressed in placenta, lung, skeletal muscle, brain > brain, kidney, liver
• expressed in:
  • apical plasma membrane of endothelium
  • alveolar epithelium

Pathology

• up-regulated in colorectal tumors
• expressed in 25% of early oral squamous cell carcinomas

More general terms

• sialoglycoprotein
• membrane protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10630
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10630
• OMIM: https://mirror.omim.org/entry/608863
• UniProt: http://www.uniprot.org/uniprot/Q86YL7.html