trans-Golgi network integral membrane protein 2; TGN38 homolog; TGN46; TGN48; trans-Golgi network protein TGN51 (TGOLN2, TGN46, TGN51)

Function

• may be involved in regulating membrane traffic to & from the trans-Golgi network

Compartment

• cell membrane; single-pass type 1 membrane protein
• Golgi, trans-Golgi network membrane
• primarily in trans-Golgi network
• cycles between the trans-Golgi network & the cell surface returning via endosomes

Alternative splicing

named isoforms=6; TGN51, TGN46, TGN48

Expression

• isoform TGN46 is widely expressed
• isoform TGN51 is more abundant in fetal lung & kidney
• isoform TGN48 is expressed at very low levels in embryonic kidney & promyelocytic cells

More general terms

• membrane protein
• glycoprotein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10618
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10618
• OMIM: https://mirror.omim.org/entry/603062
• UniProt: http://www.uniprot.org/uniprot/O43493.html